Wegovy is also an injection, but is used for the treatment of obesity
In clinical trials [2], the most common side effects were mild digestive issues, including: nausea diarrhoea vomiting constipation These symptoms were dose-related, usually mild to moderate, and often improved when the dose was increased more slowly
In standard titration, GLP-1 medications such as semaglutide or tirzepatide are initiated at very low doses and gradually increased to help the body adapt and minimize potential side effects
However, theyve gained popularity for their remarkable effects on weight loss
Together, these mechanisms help preserve neuronal homeostasis, reduce the risk of delirium and SAE, and potentially improve neurocognitive outcomes in patients with severe sepsis
Once the FDA declared shortages resolved in early 2025, that legal justification disappeared for most patients